Inducing a systemic immune response just before surgery could not only activate effector CTL deleting tumor cells expressing tumor-associated antigens (TAA) but also lead to immunologic memory that may protect against tumor recurrence over a long time by eliminating neoplastic cells presenting TAA-derived peptides in their major-histocompatibility-complex class I proteins (HLA-A, B, and C in man) leading to effective immune surveillance (29, 30). Here, HLA-A is linked to neoplasm.