As far as we know, no study has reported this phenomenon in LADC, so we proposed another hypothesis: some LADC tumor cells in patients with co-expression of VEGFA and PD-L1 may have strong ability to evade from the attacks by immune cells, so even if few immune cells infiltrate into tumor tissue, through abnormal vasculature caused by high-expressed VEGFA, they can also cause “high-response” tumor cells to express high PD-L1. Here, VEGFA is linked to neoplasm.