In fact, the effect on tumor growth in our genetic model may even be underestimated due to the incomplete deletion of Pdpn. Incomplete recombination of Pdpnflox alleles in macrophages has also been reported for the combination with another transgenic Cre-line Vav-Cre; (57), making it questionable whether the employment of another Cre-line would have resulted in more efficient PDPN deletion. This evidence concerns the gene VAV1 and neoplasm.