Immunotherapy based on and programmed death-ligand 1 (PD-L1)- and programmed death 1 (PD-1)-targeted antibodies has profoundly modified the prognostic and therapeutic landscape for many types of tumors, with demonstrated efficacy against renal cell carcinoma (RCC), non–small cell lung cancer (NSCLC), and melanoma. Here, CD274 is linked to renal cell carcinoma.