CD274 and non-small cell lung carcinoma: Immunotherapy based on and programmed death-ligand 1 (PD-L1)- and programmed death 1 (PD-1)-targeted antibodies has profoundly modified the prognostic and therapeutic landscape for many types of tumors, with demonstrated efficacy against renal cell carcinoma (RCC), non–small cell lung cancer (NSCLC), and melanoma.