Furthermore, we investigated the function of LncRNA MIR4435-2HG in colorectal cancer tissues using GSEA, and the result showed in LncRNA MIR4435-2HG high expression phenotype, pathways, like the P38/MAPK pathway, the VEGF pathway, the cell adhesion molecules cams, NOD-like receptor signaling pathway, the cell surface interactions at the vascular wall, and integrin cell surface interactions were found significantly differential enrichment. The gene discussed is VEGFA; the disease is colorectal cancer.