CEACAM5 and metastatic malignant neoplasm in the lymph nodes: Increased expression of MIR4435-2HG was correlated significantly with the grade of topography distribution (P < 0.001), lymph node metastasis (P < 0.001), stage (P < 0.001), and CEA level before treatment (P = 0.013), as shown in Figs. 2A–2E.