FGF16 and cancer: Figure 8 shows that the gene expression of FGF16 is up-regulated and the gene expression of UPF3 is down-regulated in the DH samples compared to the rest of the samples. UPF3 is a regulator of non-sense transcripts homolog B (yeast). Kechavarzi and Janga (2014) found that UPF3 is one of the actively upregulated RNA-binding proteins identified in nine cancers in humans and their cancer relevant references, and breast cancer is one of them.