IRS2 and type 2 diabetes mellitus: We found that in MCM, most adipose-specific edges appeared in links to hub gene PIK3R1, and a large proportion of them were active under T2D, such as the function occurred between PIK3R1 and INS1, the function between PIK3R1 and IRS2, the function between PIK3R1 and IGF1 etc. Taking muscle-specific edges in MCM into consideration, it can be seen that PIK3R1, PIK3CB, and EGFR were key nodes.