NF-κB showed strong interconnectivity with glucocorticoid receptor signaling pathway (Widén et al., 2003), and the role of NF-κB in context to prostate cancer has been extensively studied by our group (Shukla and Gupta, 2004; Vykhovanets et al., 2011; Shukla et al., 2015). The gene discussed is NR3C1; the disease is Familial prostate cancer.