NFKB1 and Familial prostate cancer: While the Glucocorticoid receptor signaling pathway linked directly with NF-κB complex, p38MAPK and T-cell receptors and indirectly associated with interferons (IL24), Tumor Necrosis Factor (Ligand) superfamily, Member 10 (TNFSF10), TNFSF10, and RPL10A directly linking with histone h4 complex during prostate cancer development (Figure 6A).