KLF4 and Familial prostate cancer: Similarly, top 10 genes downregulated in TRAMP mice cross-referenced with human are PPP1R3, GPR15, GPR45, TME, TGM4, KLF4, LRRN3, WNT, SPRR1A, and TMEM of which 9 out of 10 were downregulated in human prostate cancer dataset (Table 4).