The TCR showed interconnectivity with ELF2 signaling pathway, and ELF2 showed connectivity with RPS5, RPS7, RPS8, RPS10, RPS13, RPS15A, RPS17, RPS20, RPS28, and RPS29 and large; RPL5, RPL7, RPL9, RPL10A, RPL17, RPL19, RPL22, RPL23A, RPL30, RPL31, RPL38, interestingly the ribosomal protein was overwhelmed and upregulated in TRAMP mice dataset (Figure 6A), and tempted us to explore the role of ribosomal protein in prostate cancer. This evidence concerns the gene RPL22 and Familial prostate cancer.