CDKN1B and prostate carcinoma: Some established animal models include tumor suppressor knockout PTEN mouse (Wang et al., 2003); gain of function model such as the c-myc mouse (Ellwood-Yen et al., 2003); and various conditional knockouts of multiple genes including the NKX3.1 (Kim et al., 2002); p27/Kip1 knockout (Gao et al., 2004) and the p53 and retinoblastoma (Rb) double knockout mouse (Zhou et al., 2006), which correlate with possible similar alterations in human prostate cancer.