AHR plays an important role in cellular homeostasis and disease development, and the Aryl hydrocarbon receptor nuclear translocator (AHRN) forms a complex with ligand bound AHR during cancer and activates Bax, a central cell death regulator, MAPK, Aldehyde dehydrogenases (ALDHs), Glutathione transferase (GST) and others (Supplemental Figure 1). The gene discussed is HPGDS; the disease is cancer.