The selected significant features were FYN, KCNH2, REST, CDH12, LRRC8E, SCG2, PHF8, PCSK1, ANXA2, and MIR6730. FYN was an authentic Effector of oncogenic EGFR signaling, by limiting EGFR tumor cell motility (Lu et al., 2009). This evidence concerns the gene REST and neoplasm.