Strikingly and contrary to wild-type mice, no t-PA-mediated blood leukopenia (Figure 6B) and lymphopenia (Figure 6B) were observed in plg−/− mice, whereas baseline (sham) levels of monocytes were even increased, rather than reduced, by t-PA treatment (p < 0.05; Figure 6B). Here, PLAT is linked to Decreased total leukocyte count.