PLAT and Stroke: Notably, in addition to the changes induced by stroke alone, unique t-PA effects on the innate cellular immune profile could be observed; for example, while the overall cLN cellularity after MCAo was unaffected in any group (Figure 5A, left panel), cDC and macrophage proportions decreased in the lymph nodes of sham-operated mice after t-PA exposure (p < 0.05 and p < 0.01, respectively; Figure 5A).