The importance of the ethnic background for Tnfsf15 polymorphisms was further highlighted in an Indian study showing that haplotype A was significantly more frequent in IBD cases than in healthy individuals, while the opposite was observed for haplotype C. Further investigation identified two additional SNPs (rs10114470 and rs4263839) and generated 7 different haplotypes, from which haplotype H had a possible protective role being more frequent in healthy individuals, whereas haplotypes I and J conferred susceptibility to IBD (25). This evidence concerns the gene TNFSF15 and irritable bowel syndrome.