Peripheral insulin resistance is attributed to an increase in the phosphorylation of Ser307 on IRS-1; this uncouples IRS-1 from the insulin receptor blunting the ability of insulin to signal through its receptor, which, in turn, reduces GLUT4 translocation to the cell surface to facilitate glucose uptake in peripheral organs, leading to hyperglycemia (18). This evidence concerns the gene IRS1 and Insulin resistance.