IL10 and neoplasm: Furthermore, the immunosuppressive cytokine Il10 was not upregulated in the array (Supplementary Figure S3A) or in additional KPC tumor B cells by qRT-PCR (Figure 3F), it was actually downregulated in orthotopic B cells (Figure 3F), further confirming the overall B-cell population within tumors holds a more proinflammatory and likely immunostimulatory phenotype.