IUGR and/or preeclampsia can be the consequences of placental insufficiency associated with overexpression of sFlt-1 (soluble fms-like tyrosine kinase-1) a soluble form of the vascular endothelial growth factor- type 1 (VEGFR-1) (127), several weeks before the beginning of maternal clinical signs (128). This evidence concerns the gene FLT1 and placental insufficiency.