The activation of astrocytes is an early event in the development of MS lesions with the release of cytokines like CCL-2, CXCL-12, MMPs, TGFβ, IL-1, IL-6, IL-10, IL-12, IL-15, IL-23, and IL-27 leading to dysfunction of the blood-brain barrier (BBB) as well as recruitment of innate and adaptive immune cells (32). Here, IL27 is linked to myeloid sarcoma.