Nevertheless, the astrocytes in progressive MS play a more specific role in the maintenance of the local inflammation; in models of chronic EAE, levels of lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) from the activated astrocytes were elevated in the EAE-lesions. Here, B4GALT6 is linked to myeloid sarcoma.