Sex differences in the mechanisms of cell death have been described after brain injury secondary to stroke (Liu et al., 2011) and hypoxia-ischemia (Hagberg et al., 2004; Zhu et al., 2007; Northington et al., 2011; Chavez-Valdez et al., 2012) and here, we provide preliminary evidence that these differences may also occur in response to TLR3 activation in the neonatal brain. Here, TLR3 is linked to stroke disorder.