Specifically, there is a decrease of muscle and cardiac constellation ferments activity, increase of lipid metabolism derivatives, increase of erythrocytes concentration, decrease in glucose tolerance and hypercholesterolemia, and increase of insulin and serum NT-proBNP levels, which is a proxy measure for brain natriuretic peptide (Ivanova et al., 2008; Markin et al., 2008; Navasiolava et al., 2011c; Coupe et al., 2013; Pastushkova et al., 2014; De Abreu et al., 2017). The gene discussed is NPPB; the disease is Hypercholesterolemia.