Tynan et al. (2004) showed that estrogens modulate GILZ expression in MCF-7 human breast cancer cells. Again, crosstalk between the GR and ER nuclear receptor members in inflammation might be therapeutically relevant and anti-inflammatory activity of GILZ may play a relevant role in this interplay (Cuzzocrea et al., 2007). This evidence concerns the gene TSC22D3 and breast cancer.