TSC22D3 and colitis: Bereshchenko et al. (2014) showed that GILZ is necessary for GC-mediated Treg cell induction. This effect is due to GILZ interaction with SMAD proteins, thus synergizing with the TGF-β activity in enhancing FoxP3 expression (Bereshchenko et al., 2014). Notably, the therapeutic effect of GCs was lacking in a colitis model in GILZ knockout mice (Bereshchenko et al., 2014).