SPHK2 and Familial prostate cancer: In prostate cancer cells, SK2 KD has enriched RAS protein signal transduction, MAP kinase, protein serine/threonine kinase, cell motility, small GTPase and phosphatidylinositol 3-kinase signaling pathways (Supplementary Table S3, examples of linked pathways shown in Figure 6) while in breast cancer cells it induced Wnt signaling, small GTPase mediated signal transduction, MAP kinase, endosomal transport and RAS protein signal transduction pathways and downregulated DNA repair pathway (Supplementary Table S4, examples of linked pathways shown in Figure 6).