SPHK2 and cancer: In prostate cells, SK2 KD affected expression of 25 genes (Figure 4) including downregulation of capping actin protein of muscle Z-line alpha subunit 1 (CAPZA1), involved in inhibition of autophagy and epithelial-mesenchymal transition (EMT), NSUN3 (NOP2/Sun RNA methyltransferase family member 3, mRNA translation), ADP dependent glucokinase (ADPGK), involved in EMT in cancer cells and kelch domain containing 10 (KLHDC10), which regulates oxidative stress.