On the other hand, SK2 KD in breast cancer (Figure 5) has downregulated expression of integrin subunit alpha V (ITGAV), belongs to the integrin alpha chain family which may regulate angiogenesis and cancer progression and capping actin protein of muscle Z-line alpha subunit 1 (CAPZA1), regulates growth of the actin filament and increased expression of general transcription factor IIB (GTF2B), zinc finger DHHC-type containing 20 (ZDHHC20) and ST13, Hsp70 interacting protein, involved in the assembly process of glucocorticoid receptor. This evidence concerns the gene SPHK2 and breast cancer.