In breast cancer cells SK1 KD (Figure 3) has decreased the expression of E2F5 (E2F transcription factor 5), NSUN2, nuclear factor of activated T-cells 3 (NFATC3) which regulates transcription, PRPS2, cyclin dependent kinase 2 (CDK2), known regulator in the cell cycle, G3BP stress granule assembly factors G3BP1 and G3BP2, vesicle-associated membrane-protein-associated protein B (VAPB) involved in vesicle trafficking and N-acetylglucosamine kinase (NAGK), involved in metabolism. The gene discussed is E2F5; the disease is breast cancer.