In prostate cells, SK2 KD affected expression of 25 genes (Figure 4) including downregulation of capping actin protein of muscle Z-line alpha subunit 1 (CAPZA1), involved in inhibition of autophagy and epithelial-mesenchymal transition (EMT), NSUN3 (NOP2/Sun RNA methyltransferase family member 3, mRNA translation), ADP dependent glucokinase (ADPGK), involved in EMT in cancer cells and kelch domain containing 10 (KLHDC10), which regulates oxidative stress. The gene discussed is NSUN3; the disease is cancer.