NFE2L2 and Pain: In addition and due to we previously demonstrated that the activation of Nrf2 following SFN administration increased the antinociceptive effects of DOR and MOR agonists during inflammatory and neuropathic pain (McDonnell et al., 2017a; Redondo et al., 2017; Ferreira-Chamorro et al., 2018), the potential improvement of the antinociceptive effects of UFP-512 by its coadministration with SFN in animals with inflammatory or neuropathic pain was also evaluated.