Hypermethylation targets include thromboxane A2 receptor (TBXA2R), sorbin, SH3 domain containing 3 (SORBS3), and spectrin beta 4 (SPTBN4), indicating that the cyclic AMP response element-binding protein (CREB) activation pathway and the axon initial segment may contribute to AD pathology (Sanchez-Mut et al., 2013). The gene discussed is SPTBN4; the disease is Alzheimer disease.