Analysis of polymorphisms of DNMT3A and DNMT3B support a major role for these loci in the pathogenesis of late-onset AD and these polymorphisms can be used as stratification markers to predict an individual’s susceptibility to late-onset AD (Coppedè et al., 2012; Ling et al., 2016). The gene discussed is DNMT3B; the disease is Alzheimer disease.