Our experiments also demonstrated that G. lucidum alcohol extracts could improve learning and memory abilities, ameliorate neuron apoptosis and brain atrophy, and down-regulate the expression of the AD intracellular marker, Aβ1-42 in APP/PS1 AD model mice, while positive effects on DNA methylation were observed in SAMP8 and APP/PS1 mice. The gene discussed is APP; the disease is Alzheimer disease.