Since Prudente S first reported the relationship between TRIB3 missense Q84R (rs2295490) polymorphism and insulin resistance or its related cardiovascular events (Prudente et al., 2005), numerous clinical studies have confirmed the risk of genetic variant associated with vascular events, especially the deleterious role of TRIB3 R84 (Gong et al., 2009; Formoso et al., 2011; Prudente et al., 2015; Zhang et al., 2015). This evidence concerns the gene TRIB3 and Insulin resistance.