CD8A and glioblastoma: Since a high CD8+ T/Treg ratio is associated with improved overall survival, (Yue et al., 2014; Shang et al., 2015) and because there is a decreased CD8+ T/Treg ratio during advanced aging of normal human healthy individuals that is maximal in the 60–69 age group, the data collectively demonstrate a trend for increased immunosuppression in the peripheral blood coincident with the median age of a GBM patient diagnosis.