SEMA3A and multiple sclerosis: The effect of SEMA3A on vascular permeability has been proven in a previous report (Acevedo et al., 2008), but neurological research on SEMA3A is very limited, mainly focusing on ischemia stroke, multiple sclerosis lesions, and particularly the functions of SEMA3A in suppressing axon formation and promoting dendrite growth (Shelly et al., 2011; Costa et al., 2015; Hou et al., 2015; Gutierrez-Franco et al., 2016).