SHANK3 and Anxiety: Impaired learning and memory and increased anxiety behavior have often been reported in a majority of Shank3-deficient mouse models (Bozdagi et al., 2010; Bangash et al., 2011; Peca et al., 2011; Wang et al., 2011; Yang et al., 2012; Kouser et al., 2013; Duffney et al., 2015).