SHANK3 and premenstrual tension: Therefore, more Shank3 genetically modified rat models carrying different mutations need to be established and characterized, which may help to more comprehensively understand Shank3 function, species-specific phenotype differences and the phenotypical diversity of clinical manifestations observed by clinicians and researchers; additionally, an animal model with a complete Shank3 deletion can mimic the majority of patients carrying deletions of the entire Shank3 gene in PMS (Soorya et al., 2013).