Based on these findings, a potential miRNA-mRNA regulatory network contributing to GBM onset and progression was established, including miR-10b-5p/miR-181a-2-3p-PPP3CB, miR-92b-3p/miR-15b-5p-MYO5A, and miR-7-5p/miR-218-5p/miR-128-3p/miR-137-EGFR regulatory pathways. Here, EGFR is linked to glioblastoma.