The enriched pathways for candidate target genes of downregulated DE-miRNAs were pathways in cancer, cell cycle, bladder cancer, proteoglycans in cancer, small cell lung cancer, ECM-receptor interaction, PI3K-Akt signaling pathway, focal adhesion, pancreatic cancer and hepatitis B as shown in Table 2. Here, AKT1 is linked to familial pancreatic carcinoma.