HCRT and hypertensive disorder: It has also been demonstrated that the neuropeptides and transmitters in RVLM play a long-term regulatory effect on neurons excitability which may affect adaptive reflexes and encode distinct patterns of sympathetic output, and an overactive orexin system was implicated in the enhanced sympathetic vasomotor tone in the hypertension pathogenesis (Miyawaki et al., 2002; Pilowsky et al., 2008).