In the present study, EA treatment at LI11 acupoints was applied for 6 weeks in 2K1C hypertensive rats, and the results demonstrated that (1) EA treatment effectively reduced arterial BP and decreased the enhanced sympathetic activities in 2K1C rats, (2) EA treatment significantly improved the myocardial hypertrophy, and (3) EA treatment inhibited the increased OX1R expression and reversed the OX1R-mediated responses in the RVLM of the hypertensive rat. The gene discussed is HCRTR1; the disease is cardiac hypertrophy.