Lastly, among the genes found to be upregulated in the blood on WS subjects, we found the SLI candidate SETBP1, as well as FGFR1 and SIX3. SETBP1 is also a candidate for Schinzel-Giedion syndrome, a clinical condition entailing occasional epilepsy and severe developmental delay (Ko et al., 2013; Miyake et al., 2015). This evidence concerns the gene SIX3 and Global developmental delay.