Interestingly, Six3 regulates Shh (Jeong et al., 2008), one robust candidate for microcephaly that has been positively selected in the human lineage (Dorus et al., 2004), but it also interacts with several genes relevant for our language-ready brain (Benítez-Burraco and Boeckx, 2015). The gene discussed is SIX3; the disease is microcephaly.