GTF2I and Werner syndrome: To date, the most promising candidates for language dysfunction in WS are GTF2I, BAZ1B, and LIMK1. In particular, GTF2I, which encodes a regulator of transcription, has been repeatedly related to the behavioral and cognitive disabilities that are typically found in this condition and that have an impact on language function (Morris et al., 2003; Tassabehji et al., 2005; Sakurai et al., 2011; Hoeft et al., 2014).