Both GSK3β and ERK1/2 were found to be activated in control PC12-htau cells, in agreement with previous reports on AD (Figure 5) (Amadoro et al., 2006; Mazanetz and Fischer, 2007; Forlenza et al., 2011; Medina and Wandosell, 2011; Martin et al., 2013). The gene discussed is MAPK3; the disease is Alzheimer disease.