Memory impairments were prominently decreased or abolished in rats administered either CEF alone or in combination with EPO.  The co-administration of the 2 agents (CEF + EPO) showed superior action than individual agents.  CEF, EPO, or CEF + EPO also reduced or eliminated MPTP lesioning-induced neurodegeneration.  The combined administration of these agents also displayed a better outcome in the densities of DAergic terminals. This evidence concerns the gene EPO and memory impairment.