SLC1A2 and Huntington disease: CEF treatment in R6/2 mice attenuated various manifestation of HD including a decreased paw clasping and twitching, while motor flexibility and open-field climbing were amplified.  Compared to vehicle received group, CEF treated group showed an upregulation of GLT1 expression in striatum.  CEF also restored the glutamate uptake in striatum of R6/2 mice.  Upregulation of the functional GLT1 level by CEF attenuated the multiple HD behavioral phenotype.