We and others have shown that PRICKLE1 contribute to cancer cell dissemination in various cancers.2,9–11 To investigate the molecular mechanisms underlying the role of PRICKLE1 in tumorigenicity, and notably cell motility and dissemination, we generated a stable cell line expressing GFP-PRICKLE1 in the highly invasive MDA-MB-231 TNBC cell line. Here, PRICKLE1 is linked to cancer.