It contains a PET domain at the N-terminus followed by three LIM domains and a C-terminal farnesylation site.8 Recently, we and others have demonstrated the prominent role of PRICKLE1 during cancer progression.2,9–11 PRICKLE1 is a prometastatic protein and regulates oriented cell migration in various cell lines including the MDA-MB-231 prototype TNBC cell line.2,10 At the molecular level, PRICKLE1 regulates the subcellular localisation of associated proteins such as VANGL2,8,12 RICTOR,2 ARHGAP22/24,10 and LL5β11 to coordinate oriented cellular migration. The gene discussed is PRICKLE1; the disease is cancer.