BRCA1 and breast carcinoma: The risk for breast cancer to age 80 is 72% for BRCA1 mutation carriers, and 69% for BRCA2 mutation carriers; the risk for ovarian cancer is 44% for BRCA1 carriers and 17% for BRCA2 carriers.1 Several surveillance and prevention options are available with the goals of early detection and of reducing cancer incidence and mortality.