There are ten supporting alleviating genetic interactions between BPD disease genes and genes in the KEGG MAPK signaling pathway: PLAU-HRAS, PLAU-MAP2K1, TIRAP-MP3K7, TIRAP-TRAF6, TLR4-ECSIT, TNF-CHUK, TNF-RAC, FGFR2-RAC1, FGFR2-KRAS, and FGFR2-CDC42; leading to a corresponding pmed score below 0.0001. This evidence concerns the gene TLR4 and bronchopulmonary dysplasia.