The up-regulated genes have been previously associated with asthma; hyper-reactivity and allergy (CCR2, HRH2, PTEN); lung development and apoptosis (CHRNA7, RTKN2); and immune function (GIMAP4, GIMAP7, KLRC3 and CD99) (Table 3). The gene discussed is RTKN2; the disease is asthma.