Similarly, the down-regulated genes have roles in asthma and airway modeling (PTGS2, AREG, HBEGF, PLAUR, CAMP, LTF, FCAR, PDE4B, ZNF331 and IRAK2) and immune function (NR4A3, NFIL3, ADGRE3, TARM1 and ZC3H12A). Here, IRAK2 is linked to asthma.