RUNX2 and Thrombocytopenia: While WT, MYC+RUNX2-WT, and DKO mice did not show significant changes in blood counts in peripheral blood (PB) (Fig. 7a) due to the negligible populating capacities of CD45.2+ cells 3 weeks post-transplantation (Fig. 7b), MYC+RUNX2-DKO moribund mice showed robust leukocytosis, anemia, and thrombocytopenia (Fig. 7a) following the emergence and expansion of CD45.2+ cells (Fig. 7b).