The inhibition of BRD4 significantly reduced the expression of RUNX2 and MYC in BPDCN cells, and the ectopic expression of RUNX2 alone, but not MYC alone, significantly restored impaired cell growth by the inhibition of BRD4, suggesting that MYC requires BRD4 and other factors to activate the enhancers and promote the cell growth, consistent with previous findings that ectopic expression of MYC did not restore JQ1-mediated impairments in cell growth in BPDCN and prostate cancer cells12,38. The gene discussed is MYC; the disease is Familial prostate cancer.