Given the transduction of MYC in DKO leukemia cells, GSEA showed the positive enrichment of canonical MYC target genes in BPDCN cells from that in WT MDPs or WT pDCs (Fig. 8d and Supplementary Table 1), and a gene ontology analysis revealed significant enrichments in ribosome and translation-related pathways, which may be activated by MYC. This evidence concerns the gene MYC and leukemia.