The expression levels of RUNX2 were significantly higher in BPDCN cells than in AML cells and U2OS and Saos2 osteosarcoma cells as Saos2 has higher expression level of RUNX2 than normal counterpart cells and promotes the cell growth28, while the expression levels of RUNX2 were lower in BPDCN cells than in mature pDCs isolated from healthy donors (Fig. 1a). The gene discussed is RUNX2; the disease is osteosarcoma.