MYC+RUNX2-DKO leukemic cells were transplantable in secondary recipient mice with the same CD11b−CD11cmid/+B220+Bst2+ immunophenotype, and recipient mice died earlier at 2 weeks post-transplantation (the median survival, 23 days; Fig. 7c) due to severe anemia and thrombocytopenia (Supplementary Fig. 11). Here, RUNX2 is linked to anemia.