In order to determine whether the gene expression profile of MYC+RUNX2-DKO leukemic cells reflected that in human BPDCN cells, we utilized published data sets comparing CAL-1 cells and normal pDCs in humans (Supplementary Data 2)34, and found that up-regulated and down-regulated genes both significantly overlapped between these comparisons in patients and mice (Fig. 8a), confirming the relevance of this mouse model for human BPDCN. Here, MYC is linked to CD4+/CD56+ hematodermic neoplasm.