The deletion of the mutant-allele super-enhancer of RUNX2 significantly reduced the expression of MYC and impaired the proliferative capacity of BPDCN cells, indicating that the pDC-specific RUNX2 super-enhancer activates the transcription of MYC. In addition, we investigated how MYC and RUNX2 promote the transformation of BPDCN in mice lacking Tet2 and Tp53. This evidence concerns the gene MYC and CD4+/CD56+ hematodermic neoplasm.