In order to determine whether the gene expression profile of MYC+RUNX2-DKO leukemic cells reflected that in human BPDCN cells, we utilized published data sets comparing CAL-1 cells and normal pDCs in humans (Supplementary Data 2)34, and found that up-regulated and down-regulated genes both significantly overlapped between these comparisons in patients and mice (Fig. 8a), confirming the relevance of this mouse model for human BPDCN. This evidence concerns the gene RUNX2 and CD4+/CD56+ hematodermic neoplasm.