In order to clarify whether the super-enhancer of RUNX2 was physically associated with the MYC promoter on der(8), we performed a chromatin configuration capture (3 C) analysis and a target sequencing to detect the expected chromosomes 6 and 8 regions using CAL-1 cells and Jurkat T-ALL cells lacking t(6;8) (Fig. 1g and Supplementary Fig. 6). This evidence concerns the gene RUNX2 and acute lymphoblastic leukemia.