While BPDCN cells did not show the Notch-dependent MYC enhancer observed in T-ALL37, we found that CAL-1 BPDCN cells showed a H3K27ac peak of 1.7-Mb downstream enhancer of MYC equivalent to BENC module A enhancer, which was recently shown to mildly activate the expression of Myc in murine normal stem and progenitor cells29, but also known as the Brd4-mediated enhancers of Myc in murine AML cells30. Here, BRD4 is linked to acute myeloid leukemia.