GATA4 and neoplasm: In stark contrast to control group, we detected notable lung tumor nodules in 3 out of 4 mice post 10 weeks of lenti-sgGATA4 nasal inhalation (referred to as KG mice for KrasG12D/GATA4-/-) (Fig. 1g, h, Supplementary Figure 1L), further supporting the tumor suppressive function of GATA4 in vivo.