GATA4 and lung cancer: Of note, we found that GATA4 knockdown or overexpression did not significantly impact epithelial–mesenchymal transition of lung cancer cells in vitro and in vivo (supplementary Figure 4E, 4F, 4G, 4H, and 4I), consistent with earlier reports that TGFBR-SMAD signaling axis affect the senescence44.