Our results suggest that exercise training improves HFD-induced hepatic steatosis by restoring disrupted lipid-metabolism homeostasis, attenuating de novo fatty acid synthesis and uptake-related gene upregulation, as well as diminishing CYP2E1 overexpression, which can also impact lipid homeostasis (Aubert et al., 2011), closely associated with NAFLD progression, as previously described in adult patients (Mitsuyoshi et al., 2009). The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatotic liver disease.