Notably, multivariate analysis demonstrated high CD73 expression on HCC cell and was an independent indicator for predicting both TTR [HR 2.82 (1.87–4.26), P < 0.001] and OS [HR 3.35 (2.01–5.52), P < 0.001, Tables 2 and 3]. The gene discussed is NT5E; the disease is hepatocellular carcinoma.