Lui et al. analysed whole-exome sequencing data from 151 tumours and revealed frequent oncogenic mutations in 30.5% (46/151) of the cases affecting the PI3K-mTOR pathway, whereas only 9.3% (14/151) and 8% (46/151) of tumours harboured mutations in the JAK/STAT or the MAPK pathways, respectively [21]. The gene discussed is PIK3CA; the disease is neoplasm.