Interestingly, mTOR deregulation in HNSCC is the most commonly seen genomic alteration (~80–90% HNSCC) involved in aberrant mitogenic signalling, compared to other known pathways such as the JAK/STAT and MAPK, which harbour mutations in less than 10% of lesions [53,54]. This evidence concerns the gene MTOR and head and neck squamous cell carcinoma.