GRIN2B and Parkinson disease: Radiprodil, another GluN2B-selective antagonist, in combination with the selective A2A receptor antagonist Tozadenant, significantly improved motor activity both in 6-OHDA-lesioned rats and MPTP-lesioned NHP models, suggesting that the use of such a combination could lead to motor improvement to PD patients, without inducing the motor complications induced by LD therapy [151,152].