TRPV1 and migraine with aura: In one of the few recent studies addressing a potential mechanism for TRPV1 activation, the authors used two-photon in vivo imaging of anesthetized mouse to examine macrophage morphology and dendritic cell motility in the meninges in relation to cortical-spreading depression (CSD), which is thought to be the underlying basis of migraine aura and has been shown to activate meningeal nociceptors [69,70].