ACE and migraine disorder: Preventive treatments are to a large extent borrowed from other therapeutic areas, including antihypertensive agents (e.g., angiotensin-converting enzyme [ACE] inhibitors, angiotensin receptor blockers, beta blockers), antiepileptic drugs (e.g., topiramate, sodium valproate, gabapentin), tricyclic antidepressants (e.g., amitriptyline, nortriptyline), but there are also some drugs used only with migraine prevention objectives, such as flunarizine and pizotifene [1].