In this propensity score-based analysis of a before-and-after cohort study, Shin et al found that there was no mortality benefit in early administration of vitamin C and thiamine in the overall patient population; however, subgroup analysis revealed increased survival in patients with hypoalbuminemia (albumin < 3.0) or severe organ failure (SOFA >10) [15]. The gene discussed is ALB; the disease is Hypoalbuminemia.