The screen identified three categories of genetic loci that conferred survival following infection: genes encoding enzymes involved in sphingolipid or glycosphingolipid biosynthesis, including the terminal steps in Gb3 synthesis; genes associated with cell proliferation; and two genes encoding poorly characterized proteins, lysosomal associated protein transmembrane 4 alpha (LAPTM4A) and transmembrane 9 superfamily member 2 (TM9SF2). The gene discussed is LAPTM4A; the disease is infection.