The use of CD64 detection in neutrophils with second generation skin testsfor TB,6 or IFN-γ/IP-10 response to M. tuberculosis antigens inwhole-blood short-term cultures, can be combined as detection methods to provideevidence of active inflammatory disease and exposure to M.tuberculosis when evaluating a patient for TB, using only commercialtools that are currently or will soon be available. This evidence concerns the gene IFNG and tuberculosis.