This shift in MHC isoform composition reflects findings in humans with advanced stage dysferlinopathy, where muscle biopsies from quadriceps, gastrocnemius, biceps, triceps, and deltoid muscles, displayed a type I myofibre predominance of up to 80%, suggesting a selective loss of type II myofibres [53]. This evidence concerns the gene HLA-C and neuromuscular disease caused by qualitative or quantitative defects of dysferlin.