APOE and atherosclerosis: The MAC also drives atherosclerosis in apolipoprotein E knockout (ApoE null) mice on a high fat diet [44] and ApoE null mice crossed with dysferlin null mice show striking histopathology in many muscles with myofibres replaced by fat [33]: exacerbation of these histological features in double knock-out mice may reflect combined elevated levels of MAC in both null genotypes.