Many of miRNAs (15 of 24) featured in the diagnostic system are involved in the regulation of the p53 signal pathway, a smaller number of miRNAs target other important pathways, associated with PCa, including TNF– 2 genes, AMPK– 2 genes, mTOR- 1 genes, MAPK -7 genes, ERBB– 7 genes (DIANA database). Here, EGFR is linked to posterior cortical atrophy.