Although type I IFNs can regulate CD8 cytolytic activity via the induction of granzyme B (Kohlmeier et al., 2010) and as noted above, granzyme B-expressing neutrophils were reported in lung granulomas following infection with M. tuberculosis (Mattila et al., 2015), to our knowledge an interplay between type I IFNs and granzymes in neutrophil anti-microbial action has not been reported. This evidence concerns the gene CD8A and Granuloma.