However, when we used a mutant Stat3 transgenic mouse model for AD-HIES (Steward-Tharp et al., 2014), we uniformly found increased levels of type I IFN in both serum and BAL fluid after MRSA infection, suggesting a possible mechanism for the enhanced MRSA killing/lower CFU observed with neutrophils from some AD-HIES patients as well as from the AD-HIES-like Stat3 mutant transgenic mice. The gene discussed is STAT3; the disease is Alzheimer disease.