Interestingly, neutrophils from some AD-HIES patients had enhanced IL-21-independent in vitro MRSA cytotoxic activity, which could potentially relate to the augmented STAT1 responses that have been observed in CD4+ T cells (Wan et al., 2015) and neutrophils (Holland et al., 2007) from these patients. This evidence concerns the gene STAT1 and Alzheimer disease.