Interestingly, AD-HIES patient neutrophils had significantly enhanced expression of a cluster of IFNβ-responsive genes, as compared to normal donor neutrophils (Figure 7C), and we confirmed by RT-PCR that GBP1 and GBP2 were induced in neutrophils from additional donors as well (Figure 7D). The gene discussed is GBP1; the disease is Alzheimer disease.