Alport Syndrome (AS) is a clinically and genetically heterogeneous, progressive nephropathy caused by mutations in COL4A3, COL4A4, and COL4A5, which encode type IV collagen (Gubler, 2008; Hudson, Tryggvason, Sundaramoorthy, & Neilson, 2003). The gene discussed is COL4A5; the disease is Alport syndrome.