TNF and acute kidney injury: We examined the mRNAs levels of encoding pro‐inflammatory cytokines and chemokines as MCP‐1, TNF‐α, IL‐6, IL‐1β, CXCL15 (also known as IL‐8 in human) and iNOS were greatly up‐regulated in the kidney of IRI‐AKI in MIF WT mice, which were markedly suppressed after MIF deletion (Figure 4A‐F).