Immunohistochemistry also showed that TNF‐α and MCP‐1 were abundantly expressed in the kidney with an increase of F4/80+ macrophages, CD3+ T cells and neutrophils infiltration in the kidney of IRI‐AKI in MIF WT mice, these were largely suppressed after MIF deletion (Figure 4G‐I and Figure 5A and B). Here, MIF is linked to acute kidney injury.