TNF and acute kidney injury: Immunohistochemistry also showed that TNF‐α and MCP‐1 were abundantly expressed in the kidney with an increase of F4/80+ macrophages, CD3+ T cells and neutrophils infiltration in the kidney of IRI‐AKI in MIF WT mice, these were largely suppressed after MIF deletion (Figure 4G‐I and Figure 5A and B).