De novo mutations in the WIPI4 gene have been identified in five patients with SENDA (static encephalopathy of childhood with neurodegeneration in adulthood), an X-linked neurodegenerative disorder associated with childhood psychomotor retardation, sudden onset progressive dystonia-parkinsonism and dementia, plus iron deposition in the globus pallidus and substantia nigra (Saitsu et al., 2013; Seibler et al., 2018). Here, WDR45 is linked to neurodegeneration with brain iron accumulation 5.